Table 1.

Kinetic and stability data for C β-sheet mutants of α1-AT compared to wild type

Protein	SI	kass (×104) M.s−1	kass (×104) M.s−1 × SI	Tm (°C)
P1-Arg-α1-AT	1.1	10	10	58
P6′ Ala	177	substrate	—	44
P7′ Ala	3.5	13	46	58
P8′ Ala	62	substrate	—	44
P9′ Ala	15	5.1	77	58
P10′ Ala	1.1	10	10	58