Fig. 1.

Changes in loop 42–50 position induced by different ligands. Superimposition of Gly-rich loop (residues 42–50) and of helix αC of CK2α in presence of cosubstrate ATP (red), in the Apo-form (yellow), and with the inhibitors TBB (green) and emodin (cyan). The main difference is found in loop 42–50, while helix αC is perfectly superimposed in all four structures.