Neighbor-joining phylogeny of subdomains I through VII of the Haspin-related proteins and known eukaryotic protein kinases. An unrooted dendrogram is shown. Bootstrap values >500 from 1000 trials are given on branches, and the scale bar indicates distance of divergence. Members of ePK families as previously defined (Hardie and Hanks 1995) are indicated. GenBank accession numbers for those proteins (human unless otherwise stated) not identified in Figures 1 and 2 ▶ ▶ are piD261-like protein dJ28H20.2, CAC00561; Aquifex aeolicus AQ578, AAC06806; SudD-(Aspergillus)-like, AAC26080; ABC1-like protein, NP_064632; casein kinase I α1 (CKIα1), NP_001883; CKIIα1, NP_001886; MO15/CAK, CAA55785; Cdc2, A29539; B. mori Cdc2, BAA21483; mitogen-activated protein kinase-1 (MAPK1/ERK1), NP_002736; MAPK8/JNK1, NP_002741; glycogen synthase kinase 3α (GSK3α), P49840; MAPKKK1/MEKK1, Q13233; Ca2+/calmodulin kinase-1 (CaMKI), NP_003647; CaMKIIα, AAD55815; S. cerevisiae KIN1, AAA34722; Polo-(Drosophila)-like kinase, NP_005021; Protein Kinase RNA–dependent (PKR), AAA36409; Wee1, CAA43979; NimA-like protein kinase 1, G01452; Myxococcus xanthus Pkn1, AAA25402; MAPKK1/MEK1, AAA36318; Mst-3, AAB82560; S. cerevisiae Ste20, NP_011856; Pak1, NP_002567; TGF-β type II receptor, AAA61164; mixed lineage kinase-1 (Mlk1), P80192; Raf proto-oncogene, P04049; A. thaliana S-receptor kinase (SRK), T00534; focal adhesion kinase (Fak), Q05397; Fer, AAA61190; Eph, AAA36747; Src proto-oncogene, P22455; Abl proto-oncogene, P00519; insulin receptor (InsR), P06213; high affinity nerve growth factor receptor (TrkA), P04629; muscle, skeletal, receptor tyrosine kinase (MuSK), NP_005583; platelet-derived growth factor receptor α (PDGFRα), AAA60048; Ret proto-oncogene, P07949; fibroblast growth factor receptor 4 (FGFR4), P22455; Janus kinase-1 (JAK1), AAA36527; spleen tyrosine kinase (Syk), NP_003168; epidermal growth factor receptor (EGFR), P00533; β-adrenergic receptor kinase-1 (βARK1), NP_001610; Phaseolus vulgaris PvPK1, AAA33772; S. cerevisiae DBF2, AAA34559; ribosomal protein S6 kinase (p70 S6K), P23443; S. cerevisiae cAMP-dependent protein kinase SCH9, P11792; cAMP-dependent kinase catalytic subunit-α (PKA-Cα), P17612; Rac-α, AAA36539; protein kinase C-α (PKC-α), P17252; and S. pombe Csk1, AAB26194.