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Total shift in ion binding constant ΔpK, owing to solution ionic strength, is plotted as a function of the dielectric radius Rd for the SC8 model. A reference state at salt concentration cs = 1 mM is chosen and the protein (of radius Rp = 14Å) is allowed to bind two divalent cations. Results from MC simulations and TK calculations are compared as solid and broken lines, respectively.
