Table 1.

Number of heavy atoms within 7 Å distance from the Cγ of the side chaina

	Side-chain: polar atoms	Side-chain: nonpolar atoms	Backbone atoms	Total number of atoms
Val5	0	33	22	55
Val17	5	32	15	52
Gln41	1	31	23	55
Leu67	0	34	17	51

^a Calculations were done using the Protein Data Bank entry 1UBQ. For comparison, the solvent-exposed residues will have on average ∼25 total heavy atoms within 7 Å distance, and of those on average only ∼35% will belong to the nonpolar side-chain atom class.