Fig. 5.

Sequence alignment of SH3 domains whose three-dimensional structure are known either by X-ray or nuclear magnetic resonance techniques. Completely conserved W and P are shown with a dark background. The boxed columns indicate generously conserved amino acids. The secondary structure information is given at the top; β-strands are labeled B1 to B5 and the 310-helix is labeled H1. RT-loop, n-src loop (nL), and distal loops (dL) are labeled. (chspec) Chicken spectrin; (drosem5) drosophila sem-5; (hugrb2c) human growth factor receptor bound protein 2 C-terminal domain; (raapsin) rat amphiphysin; (hupi3k) human phosphotidyl inositol-3-kinase; (moueps8) mouse eps8; (hugrb2n) human growth factor receptor bound protein 2 N-terminal domain; (hucsk) human c-src kinase; (mouccrkn) mouse c-crk N-terminal domain; (hubtk) human bruton tyrosine kinase; (chsrc) chicken src; (hufyn) human fyn; (huhck) human hck; (hulck) human lck; (huneb) human nebulin; (mouabl) mouse abl; (huplcg) human plc-gamma.