Skip to main content
. 2001 Oct;10(10):2050–2062. doi: 10.1110/ps.12101

Table 1.

Binding properties of rCRFR1, rCRFR1-Kif, and rCRFR1-NT-Kif

Peptide (radioligand used) rCRFR1 KD or KI [nM] rCRFR1-Kif KD or KI [nM] rCRFR1-NT-Kif KD or KI [nM]
rUcn ([125I-Tyr0]-rUcn) 0.61 ± 0.05 (n = 3) 0.79 ± 0.17 (n = 3) 27 ± 10 (n = 4)
h/rCRF ([125I-Tyr0]-h/rCRF) 1.0 ± 0.2 (n = 3) 1.2 ± 0.2 (n = 2) no binding
Ast ([125I-Tyr0]-rUcn) 4.9 ± 1.0 (n = 3) 3.4 ± 0.4 (n = 3) 60 ± 24 (n = 3)

The affinity constants are mean ± sdv of n independent binding experiments performed in duplicate. KD values were calculated for rUcn and h/rCRF and KI values for Ast.