Table 4. Space–time interaction between the dates and places of diagnosis of childhood acute leukaemia in France 1990–2000 (Knox, 1964).
|
Time t (months)
|
||||||
|---|---|---|---|---|---|---|
| Age (y) | Distance d (km) | 1 | 3 | 6 | 9 | 12 |
| 0–14 | 0 | 0.94 (764) | 0.95 (1804) | 0.99 (3442) | 0.99 (4970) | 1.00 (6502) |
| 5 | 0.98 (1458) | 0.98 (3398) | 1.00 (6330) | 1.00 (9116) | 1.00 (11884) | |
| 10 | 1.00 (4082) | 0.99 (9448) | 1.00 (17386) | 1.00 (25260) | 1.00 (32768) | |
| 15 | 1.01 (7252) | 0.99 (16596) | 1.00 (30604) | 1.00 (44414) | 1.00 (57826) | |
| 20 | 1.01 (10632) | 1.00 (24456) | 1.00 (44850) | 1.01 (65066) | 1.01 (84752) | |
| 30 | 1.01 (16568) | 1.00 (38124) | 1.00 (69784) | 1.00 (101274) | 1.01 (132026) | |
| 50 | 1.00 (25302) | 1.00 (58470) | 1.00 (107350) | 1.00 (155570) | 1.00 (202860) | |
| 0–4 | 0 | 1.04 (284) | 0.93 (588) | 1.00 (1162) | 1.00 (1680) | 1.00 (2196) |
| 5 | 1.04 (476) | 1.00 (1052) | 1.04 (2012) | 1.01 (2828) | 1.01 (3680) | |
| 10 | 1.03 (1238) | 1.02 (2814) | 1.02 (5174) | 1.01 (7410) | 1.00 (9604) | |
| 15 | 1.04 (2144) | 1.02 (4860) | 1.02 (8950) | 1.01 (12774) | 1.01 (16632) | |
| 20 | 1.02 (2954) | 1.02 (6866) | 1.02 (12572) | 1.02 (18190) | 1.02 (23682) | |
| 30 | 1.02 (4520) | 1.02 (10418)* | 1.01 (18972) | 1.01 (27458) | 1.01 (35832) | |
| 50 | 1.00 (6698) | 1.00 (15496) | 1.00 (28506) | 1.00 (41236) | 1.01 (53866) | |
| 5–9 | 0 | 0.81 (46) | 0.95 (124) | 1.00 (238) | 0.95 (328) | 1.00 (444) |
| 5 | 0.95 (102) | 1.00 (248) | 0.99 (450) | 0.97 (634) | 0.98 (828) | |
| 10 | 0.99 (304) | 0.97 (690) | 0.98 (1266) | 0.98 (1830) | 0.98 (2372) | |
| 15 | 1.01 (542) | 1.03 (1280) | 0.99 (2256) | 1.00 (3288) | 1.02 (4316) | |
| 20 | 1.01 (820) | 1.03 (1928) | 0.97 (3332) | 0.99 (4862) | 1.00 (6410) | |
| 30 | 0.99 (1282) | 1.02 (3050) | 0.98 (5342) | 0.99 (7784) | 1.00 (10222) | |
| 50 | 0.98 (2040) | 1.01 (4882) | 0.99 (8720) | 1.00 (12734) | 1.01 (16562) | |
| 10–14 | 0 | 1.00 (20) | 1.13 (52) | 1.32 (112)* | 1.20 (148) | 1.15 (184) |
| 5 | 0.85 (42) | 1.03 (118) | 1.15 (242) | 1.12 (342) | 1.09 (432) | |
| 10 | 0.86 (126) | 0.92 (312) | 0.96 (600) | 0.98 (886) | 1.00 (1168) | |
| 15 | 0.92 (250) | 0.97 (608) | 1.05 (1210) | 1.05 (1746) | 1.01 (2190) | |
| 20 | 0.96 (392) | 0.98 (924) | 1.00 (1734) | 1.00 (2520) | 0.99 (3226) | |
| 30 | 0.99 (648) | 0.99 (1490) | 0.99 (2750) | 0.99 (3990) | 0.99 (5162) | |
| 50 | 0.97 (982) | 1.00 (2344) | 1.00 (4288) | 1.00 (6222) | 1.00 (8084) | |
*
P<0.05.
These figures refer to O/E (O).
O is the observed number of close pairs of cases (up to d kilometres and t months apart) among n(n−1)/2 possible pairs, n being the total number of cases in the period and age group under consideration.
E is the number of close pairs expected under the hypothesis of no interaction.The statistical thresholds were evaluated as the one-sided tail probability of the distribution of O under the null hypothesis (499 Monte Carlo simulations).
Bold highlights the main results, those associated to a P-value <5%.