Figure 3.

Lattice contacts in crystals of the rat endophilin SH3 domain. Each molecule interacts with three neighbors. The central (yellow) molecule is shown with its three interaction partners. The ligand-binding groove of the yellow molecule interacts with proline and lysine residues from the N-terminus of the gray molecule; the N-­terminus of the yellow molecule interacts with the ligand-binding groove of the green molecule in an identical fashion. The details of this interaction can be seen in Fig. 4 ▶, which shows a close-up view of the region enclosed in the gray box.