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. 2008 Jan 16;10(1):R6. doi: 10.1186/ar2354

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Copyright © 2008 Koufany et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Modulation of body weight gain by rosiglitazone and pioglitazone in the course of adjuvant-induced arthritis. Male Lewis rats were sensitized subcutaneously on the basis of the tail with a single injection of 1 mg of M. tuberculosis. Animals were treated daily with 3 mg/kg (n = 6) or 10 mg/kg (n = 12) of rosiglitazone (ROSI) or 3 mg/kg (n = 6), 10 mg/kg (n = 6) or 30 mg/kg (n = 12) of pioglitazone (PIO) by oral administration. Arthritic (adjuvant-induced arthritis (AIA)) (n = 11) and normal controls (n = 10) were given 0.5% carboxymethylcellulose alone. Data are expressed as means ± SEM. *, P < 0.05 compared with normal controls; ^#, P < 0.05 compared with AIA controls (ANOVA and Fisher's PLSD post-hoc test). Dn, day n.