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. 2008 Jan 16;10(1):R6. doi: 10.1186/ar2354

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Copyright © 2008 Koufany et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of rosiglitazone and pioglitazone treatment on histological grading of ankle lesions during adjuvant-induced arthritis. Animals were treated daily for 21 days with rosiglitazone (ROSI) 10 mg/kg (n = 8) or pioglitazone (PIO) 30 mg/kg (n = 8) by oral administration. Arthritic (adjuvant-induced arthritis (AIA)) (n = 7) and normal controls (n = 7) were given 0.5% carboxymethylcellulose alone. Cartilage degradation and bone erosion were graded as indicated in the Materials and methods section. Data are expressed as means ± SEM for five representative animals per group. *, P < 0.05 compared with normal controls; ^#, P < 0.05 compared with AIA controls (Mann–Whitney U test).