. 2008 Jan 16;10(1):R6. doi: 10.1186/ar2354

Table 6.

Effect of PPAR-γ agonists on biochemical markers of bone turnover in rats with adjuvant arthritis

Group	Change in plasma osteocalcin^a(ng/ml)	Change in urinary deoxypyridinoline^b(nmol/mmol creatinine)
Normal controls	-39 ± 11	-3 ± 6
AIA controls	-50 ± 9	24 ± 7*
AIA + ROSI 10	-37 ± 12	9 ± 4
AIA + PIO 30	-32 ± 16	12 ± 5

PPAR, peroxisome proliferator-activated receptor; AIA, adjuvant-induced arthritis; ROSI 10, rosiglitazone 10 mg/kg/day; PIO 30, pioglitazone 30 mg/kg/day. Data are expressed as means ± SEM (n = 5 for deoxypyridinoline; n = 6 for osteocalcin).

*, P < 0.05 compared with normal controls (ANOVA and Fisher's PLSD test). ^aDay 21 minus day -1; ^bday 21 minus day 0.