Table 1.
Demographic characteristics of severe sepsis patients with and without invasive fungal infection
| Variables | Severe sepsis patients with IFI (n = 90) | Severe sepsis patients without IFI (n = 228) | P value |
| Baseline descriptors | |||
| Age (years) | 65 (50–76.25) | 61.5 (45–73) | NS |
| Sex (male; n [%]) | 57 (63.3%) | 149 (65.4%) | NS |
| Admission APACHE II score (mean [IQR]) | 21 (17–27) | 18 (13–23) | 0.001 |
| Admission SOFA score(mean [IQR]) | 8 (6–12) | 8 (5–11.75) | NS |
| Comorbidity (n [%]) | 71 (78.9%) | 165 (72.4%) | NS |
| Cancer (n [%]) | 14 (15.6%) | 24 (10.5%) | NS |
| Diabetes mellitus (n [%]) | 15 (16.7%) | 26 (11.4%) | NS |
| Interventions | |||
| Mechanical ventilation (n [%]) | 71 (78.9%) | 75 (32.9%) | <0.001 |
| Central venous catheterization (n [%]) | 74 (82.2%) | 122 (53.5%) | <0.001 |
| Urinary catheterization (n [%]) | 84 (93.3%) | 137 (60.1%) | <0.001 |
| Arterial catheterization (n [%]) | 51 (56.7%) | 112 (49.1%) | NS |
| Total parenteral nutrition (n [%]) | 49 (54.4%) | 99 (43.4%) | NS |
| Corticosteroids or immunodepressant drugs (n [%]) | 22 (24.4%) | 45 (19.7%) | NS |
| Renal replacement therapy (n [%]) | 21 (23.3%) | 28 (12.3%) | 0.024 |
| Outcomes | |||
| ICU LOS (days; mean [IQR]) | 16 (7.75–31) | 5 (2–10) | <0.001 |
| Hospital LOS (days; mean [IQR]) | 29.5 (17.75–50.25) | 19 (10.25–36) | <0.001 |
| Daily costs ($; mean ± SD) | 520 ± 319 | 481 ± 437 | NS |
| Hospital costs ($; mean ± SD) | 17,051 ± 14,183 | 8,474 ± 9,484 | 0.001 |
| Hospital mortality | 61 (67.8%) | 94 (41.2%) | <0.001 |
APACHE, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit; IQR, interquartile range; IFI, invasive fungal infection; LOS, length of stay; NS, not significant; SD, standard deviation; SOFA, Sequential Organ Failure Assessment.