Table 5.
Comparison between severe septic patients with and without IFI in the matched cohort study
| Variable | Severe sepsis patients with IFI (n = 60) | Severe sepsis patients without IFI (n = 60) | P value |
| Baseline descriptors | |||
| Age (years; mean [IQR]) | 67.5 (52.25–75.75) | 68 (54–74) | NS |
| Admission APACHE II score (mean [IQR]) | 20 (16.25–25) | 20 (16.25–23.75) | NS |
| Admission SOFA score (mean [IQR]) | 8 (6–10.75) | 8 (5–12) | NS |
| Co-morbidity (n [%]) | 47 (78.3%) | 48 (80.0%) | NS |
| Cancer (n [%]) | 9 (15.0%) | 11 (18.3%) | NS |
| Diabetes mellitus (n [%]) | 10 (16.7%) | 9 (15.0%) | NS |
| Interventions | |||
| Mechanical ventilation (n [%]) | 49 (81.7%) | 24 (40.0%) | <0.001 |
| Central venous catheterization (n [%]) | 51 (85.0%) | 35 (58.3%) | <0.001 |
| Urinary catheterization (n [%]) | 58 (96.7%) | 36 (60.0%) | <0.001 |
| Arterial catheterization (n [%]) | 41 (68.3%) | 35 (58.3%) | NS |
| Total parenteral nutrition (n [%]) | 35 (58.3%) | 23 (38.3%) | 0.036 |
| Corticosteroids or immunodepressant drugs (n [%]) | 13 (21.7%) | 16 (26.7%) | NS |
| Renal replacement therapy (n [%]) | 12 (20.0%) | 11 (18.3%) | NS |
| Outcomes | |||
| ICU LOS (days; mean [IQR]) | 17.5 (10–31) | 6.5 (3–10) | <0.001 |
| Hospital LOS (days; mean [IQR]) | 30 (19.25–50) | 20 (10.25–38.5) | 0.020 |
| Mean daily costs ($; mean ± SD) | 592 ± 326 | 469 ± 396 | NS |
| Hospital costs ($; mean ± SD) | 17,951 ± 15,470 | 10,023 ± 12,347 | 0.038 |
| Hospital mortality (n [%]) | 42 (70.0%) | 42 (50.0%) | 0.023 |
APACHE, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit; IQR, interquartile range; IFI, invasive fungal infection; LOS, length of stay; NS, not significant; SD, standard deviation; SOFA, Sequential Organ Failure Assessment.