Figure 3.

COP and BLOC interaction networks. (a) Sequence identity between human and insects of coatomer protein (COP)-1 proteins. The nine subunits of coatomer COP-1 are listed. The level of identity (%) between human and each of the four insect sequences is shown. The blue bars are color coded for the insect representatives as indicated. Note that for all proteins except CopE, the conservation level relative to the human ortholog is not different across the insects. Missing bars are due to missed annotations (as in Table 1 and Additional data file 3). (b) Biogenesis of lysosome-related organelles complex (BLOC)-1 in insects. The graph is based on confirmed interactions according to STRING scoring (see Materials and methods) for the eight subunits of mammalian BLOC-1. The identified homology to the fly (F), beetle (B), honeybee (H), and mosquito (M) are marked. Empty frame indicates no identified homologs in insects; small case letter indicates high sequence similarity that is only valid for a partial sequence. The interaction graph is based on identifying pair-wise interactions in BLOC-1. Information on individual subunits is available in Additional data file 2.