Figure 1.

Diagrammatic representation of the evolutionary history of chromosome 17. Marker order arrangement in the studied species, from which the arrangements of the mammalian ancestor (MA) and primate ancestor (PA) were derived (see text). The black letters on the left of each chromosome refer to the panel of BAC probes used in FISH experiments and reported in Table 1. Letters on the F. catus (FCA) chromosome refer to BACs reported in Additional data file 2 obtained by library screening. E* and J1* indicate the cat probes obtained by library screenings and corresponding to human E and J1 probes. The hash symbol for M. musculus (MUS) indicates the arrangement was derived from Zody et al. [13]. Letters in green or blue indicate BAC probes derived from literature data (see text for details). In red are additional BACs used to delimit the breakpoints or those that yielded duplicated signals. The time of divergence is reported near the arrow. The 'N' in the red circle indicates an evolutionary neocentromere. CJA, Callitrix jacchus; CMO, Callicebus moloch; GGO, Gorilla gorilla; HA, hominoid ancestor; HSA, Homo sapiens; LLA, Lagotrix lagotricha; MMU, Macaca mulatta; NWM, New World monkey; OWM, Old World monkey; PPY, Pongo pygmeus; PTR, Pan troglodytes. Red and green regions indicate human short and long arm respectively; black bands are the Giemsa cytobands of chromosome 17, letters in color reported further BAC probes used to refine breakpoints (see the text for details) and gray segments and numbers report the human chromosomes sharing sintenic association with chromosome 17.