Table 1.

Additional myeloid transcription factors identified by PAP

Cluster	Accession	TF	Symbol	Association with myeloid development	Reference
UP0	MA0081	SPI-B	Spib	Can functionally replace PU.1 in myeloid development	[85]
	M00961	VDR	Vdr	Involved in monocytic differentiation in human leukemia cells	[86]
	M00777	STAT	Stat4	Expressed in early myeloid development	[79]
	MA0103	deltaEF1	Zfhz1a
	M00655	PEA3	Etv4
UP1	M00161	Oct-1	Pou2f1	Regulates PU.1	[87]
UP7	M00658	PU.1	Sfpi1	Known regulator of hematopoiesis	[88]
	M00329	Pax-9	Pax9
	M00925	AP-1	Jun	Known regulator of myeloid development	[89]
	M01031	HNF4	Hnf4a
	MA0081	SPI-B	Spib	Can functionally replace PU.1 in myeloid development	[85]
UP01	M00217	USF	Usf1	Regulates HOXB4 in normal and leukemia stem cells	[90]
	M00792	SMAD	Smad1
	M00805	LEF1	Lef1	Expression altered in acute leukemia	[77]
	M00799	Myc	Myc	Upregulated in AML and induces AML	[91]
	MA0002	AML-1	Runx1	Known regulator of hematopoiesis	[88]
UP67	M00133	Tst-1	Pou3f1
	M00188	AP-1	Jun	Known regulator of myeloid development	[89]
	M00729	Cdx-2	Cdx2	Involved in the ETV6-CDX2 fusion protein	[92]
	M00912	C/EBP	Cebpa	Known regulator of hematopoiesis	[88]
	M00162	Oct-1	Pou2f1	Regulates PU.1	[87]

PAP was used to identify overrepresented TF binding sites in each coexpressed gene clusrer. Almost all of these TFs are associated with myeloid development or myeloid leukemia.