Table 4.
Transcription factors in the normal myeloid genetic network regulated by dysregulated transcription factors in APL
| Differentially expressed TFs in APL | Regulated TFs in normal myeloid development | P value |
| Arid5b | Rora | ~0 |
| Arid5b | Tcf7 | 0.0019 |
| Atf1 | Egr1 | ~0 |
| Atf1 | Hlf | 0.0041 |
| Atf1 | Rora | 0.0015 |
| Atf1 | Smad7 | 0.0015 |
| Fos | Egr2 | 0.0005 |
| Fos | Rora | ~0 |
| Fos | Tcf7 | 0.0036 |
| Fos | Zfhx1a | 0.0005 |
| Mybl2 | Rora | ~0 |
| Rxra | Egr1 | 0.0003 |
| Rxra | Etv4 | 0.0014 |
| Stat5b | Foxo1 | 0.0005 |
These regulatory targets were identified using permutation of TF binding sites.