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. Author manuscript; available in PMC: 2009 Apr 15.
Published in final edited form as: Free Radic Biol Med. 2008 Feb 7;44(8):1677–1686. doi: 10.1016/j.freeradbiomed.2008.01.022

Figure 7. MnSOD gene dosage affects the onset of tumorigenesis in Lck-Bax38/1 transgenic mice.

Figure 7

Kaplan-Meier lymphoma free survival analysis of Lck-Bax38/1 mice on backgrounds expressing various levels of MnSOD is shown. MnSOD +/+ (●), MnSOD +/− (□), and Lck-MnSOD (♦) mice were followed for lymphoma free survival as described in the Materials and Methods. Lymphoma formation in Lck-Bax38/1 mice was significantly (P=0.015) accelerated in MnSOD +/− mice compared to Lck-MnSOD transgene positive mice. Tumor formation of the MnSOD +/+ Lck-Bax38/1 was not significantly different from either the MnSOD +/− (P=0.062) or Lck-MnSOD (P=0.400) but survival of these mice was intermediate between the groups supporting a dose response relationship between tumor formation and MnSOD expression levels.