. Author manuscript; available in PMC: 2008 Jun 1.

Published in final edited form as: Bioorg Med Chem. 2007 Mar 18;15(11):3597–3623. doi: 10.1016/j.bmc.2007.03.041

Table 10.

In vitro cytotoxicity and binding efficacy of 92 and peptide free PTX-PEG-OH (95).

Compound	% binding of [¹²⁵I]-Try³-BBN cell lines		IC₅₀ (nM)

	BNR 11 cell line	NCI-H1299 cell line	NCI-H1299 cell line
			12h	96h

PTX	-	-	35	15
No inhibitor	70	19	ND	ND
BBN [7-13]	14	3.6
PTX-PEG-	ND	ND	72	44
OH (95)
PTX-PEG-	5.4	4.5	14	6
BBN (92).