. Author manuscript; available in PMC: 2008 Jun 1.

Published in final edited form as: Bioorg Med Chem. 2007 Mar 18;15(11):3597–3623. doi: 10.1016/j.bmc.2007.03.041

Table 3.

Half lives in DTT buffered solution (pH 7), in vitro cytotoxicity of the PTX and dithio-PTX prodrugs 17a–c against L2987 lung carcinoma cells

Compound	Half life of prodrug to release PTX in DTT buffer (min)	IC₅₀ (μM) of the compound	IC₅₀ (μM) of the compound + DTT
PTX		0.2
17a	12	5.7	0.2
17b	60	10.1	0.4
17c	25	130.0	2.3
18	4	6.2	0.2