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. Author manuscript; available in PMC: 2008 Jun 1.
Published in final edited form as: Bioorg Med Chem. 2007 Mar 18;15(11):3597–3623. doi: 10.1016/j.bmc.2007.03.041

Table 4.

In vitro cytotoxicity of PTX and prodrugs 20a–d and 25

Compound ID50 (ng/mL)*

H226 IGROV MCF7 EVSA-T WIDR M19 A498
PTX <0.003 0.010 <0.003 <0.003 <0.003 <0.003 <0.003
20a 41 19 16 11 13 45 40
20b 21 11 6.6 7.2 10 17 38
20c 25 26 6.9 5.2 11 24 45
20d 48 45 >63 >63 47 47 >63
25 16 27 9.2 9.3 11 20 >60
*

MCF-7, EVSA are breast carcinoma, WIDR are colon, IGROV are ovarian carcinoma, M19 are melanoma, A498 renal carcinoma, H226 non small cell lung carcinoma, cell lines