. Author manuscript; available in PMC: 2008 Jun 1.

Published in final edited form as: Bioorg Med Chem. 2007 Mar 18;15(11):3597–3623. doi: 10.1016/j.bmc.2007.03.041

Table 4.

In vitro cytotoxicity of PTX and prodrugs 20a–d and 25

Compound	ID₅₀ (ng/mL)^*

	H226	IGROV	MCF7	EVSA-T	WIDR	M19	A498
PTX	<0.003	0.010	<0.003	<0.003	<0.003	<0.003	<0.003
20a	41	19	16	11	13	45	40
20b	21	11	6.6	7.2	10	17	38
20c	25	26	6.9	5.2	11	24	45
20d	48	45	>63	>63	47	47	>63
25	16	27	9.2	9.3	11	20	>60

MCF-7, EVSA are breast carcinoma, WIDR are colon, IGROV are ovarian carcinoma, M19 are melanoma, A498 renal carcinoma, H226 non small cell lung carcinoma, cell lines