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. Author manuscript; available in PMC: 2008 Jun 1.
Published in final edited form as: Bioorg Med Chem. 2007 Mar 18;15(11):3597–3623. doi: 10.1016/j.bmc.2007.03.041

Table 5.

In vitro cytotoxicity of PTX and drug conjugates 31–34.

Compound IC50 (nM) IC50 (nM)
A2780 PC-3 MDA-MB-231 MCF-7
ER-β-(−) ER-β-(+) ER-α-(−) ER-α-(+)
PTX 25 77 4.5 4.9
31 180 73 22 39
32 680 40 51 62
33 8300 120 2200 1600
34 1900 68 304 103