Table 8.
In vitro cytotoxicity of taxoid prodrug conjugates 66, 74–76
| Taxoid | IC50 Compound/IC50 of the parent | IC50 of compound + β-glucuronidase |
|---|---|---|
| PTX | 90nM | |
| 66 | 722 | 100nM |
| 74 | 153 | NA |
| 75 | 337 (DTX) | NA |
| 76 | 187 | NA |
| 68 | 3000 | NA |
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