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. Author manuscript; available in PMC: 2008 Jun 1.
Published in final edited form as: Bioorg Med Chem. 2007 Mar 18;15(11):3597–3623. doi: 10.1016/j.bmc.2007.03.041

Table 9.

In vitro cytotoxicity of PTX-FA conjugates 85–88.

(ED50 μg/mL) T½ (h) at 37°C
A549 lung MCF-7 breast HT-29 colon pH 7 pH 5
PTX 2 × 10−2 5 × 10−2 3 × 10−2
85 1.6 ×10−3 3 × 10−3 1.2 × 10−3 1 17
86 1.2 × 10−3 2.4 × 10−3 1 × 10−3 9 38
87 1.7 × 10−3 3.3 × 10−3 2.9 × 10−3 40 >300
88 1.6 × 10−3 2.6 × 10−3 1.1 × 10−3 109 197