Table 3.

Patient percentages reporting frequent adverse events during treatment (frequent adverse events are those reported in 10% or more of patients).

Adverse event	DISULF N=53	NTX N=52	DISULF+NTX N=49	PLAC N=54
Headache	68%	63%	73%	54%
Drowsiness	42%	40%	49%	28%
Anxiety/irritability	55%	46%	61%	52%
Nausea**	42%	38%	57%	26%
Upper respiratory tract infection	45%	38%	43%	50%
Decreased sexual desire	32%	29%	33%	28%
Increased sexual desire*	11%	19%	33%	28%
Vomiting	17%	23%	29%	19%
Skin rash	15%	8%	10%	9%
Difficulty achieving orgasm	17%	13%	14%	9%
Toothache	15%	21%	10%	11%
Diarrhea	13%	8%	8%	12%

DISULF = disulfiram; NTX = naltrexone; PLAC = placebo

^*p = 0.05;

^**p = 0.01