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Distribution of absolute change in burden of disease (BOD) from baseline to week 48 in the two treatment groups. For presentation purposes, two patients receiving interferon (IFN) beta-1a, 44 mcg subcutaneously (sc) three times weekly (tiw), were removed from this plot; one patient had an extreme increase from baseline value of 56868.5 mm3 and another had an extreme reduction from baseline of 23453.6 mm3 percent changes in BOD. im, intramuscular; qw, once weekly.
