Figure 5.
Loss of function is due to the N-glycan at the interface between the VFTs. (A) Comparison of the IP production stimulated by the GB1ASA NXS/T and QXS/T mutants. (B) Similar comparison of IP stimulation for the GB2 mutants. Data are means±s.e. of at least three independent measurements. (C) Effect of CGP7930 on Ca2+ signals in cells expressing the indicated GB2 mutants. Data are means±s.e. of triplicates from a typical experiment.