Table 2.

Outcome Type	Outcomes Sub-Categories	Treatment group (n = 287)
		Gatifloxacin n = 145	Azithromycin n = 142	p-Value
Primary	Fever Clearance Time in hours (95% CI)	106 (94–118)	106 (88–112)	0.984 ˆ
Secondary	Overall treatment failure, numbers of patients (%)	13/145 (9)	13/140 (9.3)¶	0.854 ˆ
	Did not complete full treatment course, n (%)	0	2
	*Clinical failure, n (%)	6/145 (4.3)	6/140 (4.2)	1.000#
	*Microbiological failure, n (%)	2/145 (1.4)	3/140 (2.2)	0.680#
	*Typhoid-fever related complications, n (%)	0/145 (0)	8/140 (5.7)	0.003#
	Gastrointestinal bleeding	0	4
	Pneumonia	0	2
	Liver dysfunction	0	2
	Relapse after discharge from hospital, n (%)	4/137 (2.9)	0/127 (0)	0.052 ˆ
	§Number of patients with faecal carriage at follow-up, n (%)	1/137 (0.7)	0/131 (0)

*Patients can fail in more than one subcategory.

^¶In the worst case scenario: 15/142 (10.6%) showed overall treatment failure in the azithromycin group, log rank test p = 0.570.

ˆThe p value is based on the log rank test.

^#The p value is based on Fisher's exact test.

^§Evaluated in patients who attended at least two follow-up visits.