Table 1. Differentially expressed mRNA upon in vitro senescence.
Genname | Short Cut | Affymetrix ID | Log2ratio | SD |
Up-regulated in senescent passages | ||||
glycoprotein (transmembrane) nmb | GPNMB | 201141_at | 4.17 | 1.01 |
Regeneration-associated muscle protease homolog | RAMP | 213661_at | 3.94 | 1.03 |
mannosidase, alpha, class 1C, member 1 | MAN1C1 | 218918_at | 3.77 | 1.17 |
glucosaminyl (N-acetyl) transferase 3, mucin type | GCNT3 | 219508_at | 3.71 | 1.05 |
glycoprotein (transmembrane) nmb | GPNMB | 1554018_at | 3.39 | 0.79 |
secretogranin II (chromogranin C) | SCG2 | 204035_at | 3.33 | 1.04 |
hypothetical protein LOC119548 | LOC119548 | 1558846_at | 3.08 | 0.62 |
PERP, TP53 apoptosis effector | PERP | 217744_s_at | 2.83 | 0.30 |
mucolipin 3 | MCOLN3 | 229797_at | 2.66 | 0.48 |
ectonucleotide pyrophosphatase/phosphodiesterase 5 | ENPP5 | 227803_at | 2.64 | 0.76 |
cathepsin K (pycnodysostosis) | CTSK | 202450_s_at | 2.64 | 0.35 |
activating transcription factor 3 | ATF3 | 202672_s_at | 2.35 | 0.53 |
leucine-rich repeat-containing G protein-coupled receptor 7 | LGR7 | 231804_at | 2.28 | 0.10 |
disabled homolog 2, mitogen-responsive phosphoprotein | DAB2 | 240873_x_at | 2.27 | 0.31 |
solute carrier family 11, member 2 | SLC11A2 | 203124_s_at | 2.08 | 0.34 |
Homo sapiens transcribed sequences | 229308_at | 2.06 | 0.47 | |
lymphocyte antigen 96 | LY96 | 206584_at | 2.04 | 0.43 |
DnaJ (Hsp40) homolog, subfamily B, member 4 | DNAJB4 | 203811_s_at | 2.00 | 0.30 |
solute carrier family 16, member 6 | SLC16A6 | 230748_at | 1.89 | 0.30 |
solute carrier family 11, member 2 | SLC11A2 | 203123_s_at | 1.88 | 0.06 |
signal transducer and activator of transcription 1 | STAT1 | 209969_s_at | 1.75 | 0.33 |
hypothetical protein dJ462O23.2 | DJ462O23.2 | 214579_at | 1.74 | 0.14 |
GM2 ganglioside activator protein | GM2A | 1559776_at | 1.71 | 0.33 |
signal transducer and activator of transcription 1 | STAT1 | M97935_MA_at | 1.71 | 0.26 |
interferon-induced protein with tetratricopeptide repeats 1 | IFIT1 | 203153_at | 1.68 | 0.13 |
hypothetical protein FLJ31715 | FLJ31715 | 1553775_at | 1.53 | 0.12 |
clone IMAGE:3632546 | LOC643988 | 227185_at | 1.50 | 0.10 |
carbonic anhydrase XI | CA11 | 209726_at | 1.48 | 0.18 |
prion protein (p27-30) | PRNP | 215707_s_at | 1.37 | 0.15 |
SEC14-like 4 (S. cerevisiae) | SEC14L4 | 239492_at | 1.31 | 0.11 |
chromosome 20 open reading frame 22 | C20orf22 | 228123_s_at | 1.28 | 0.10 |
glutaredoxin (thioltransferase) | GLRX | 209276_s_at | 1.23 | 0.09 |
Down-regulated in senescent passages | ||||
chemokine (C-X-C motif) ligand 6 | CXCL6 | 206336_at | −2.09 | 0.23 |
hyaluronan synthase 1 | HAS1 | 207316_at | −2.40 | 0.22 |
retinoic acid receptor responder (tazarotene induced) 1 | RARRES1 | 221872_at | −4.31 | 0.82 |
tumor necrosis factor (ligand) superfamily, member 11 | TNFSF11 | 210643_at | −6.10 | 1.46 |
36 Genes that were significantly differentially expressed between early and senescent passage of three independent donor samples (SAM, FDR = 3).