Skip to main content
. 2008 May 21;3(5):e2213. doi: 10.1371/journal.pone.0002213

Table 1. Differentially expressed mRNA upon in vitro senescence.

Genname Short Cut Affymetrix ID Log2ratio SD
Up-regulated in senescent passages
glycoprotein (transmembrane) nmb GPNMB 201141_at 4.17 1.01
Regeneration-associated muscle protease homolog RAMP 213661_at 3.94 1.03
mannosidase, alpha, class 1C, member 1 MAN1C1 218918_at 3.77 1.17
glucosaminyl (N-acetyl) transferase 3, mucin type GCNT3 219508_at 3.71 1.05
glycoprotein (transmembrane) nmb GPNMB 1554018_at 3.39 0.79
secretogranin II (chromogranin C) SCG2 204035_at 3.33 1.04
hypothetical protein LOC119548 LOC119548 1558846_at 3.08 0.62
PERP, TP53 apoptosis effector PERP 217744_s_at 2.83 0.30
mucolipin 3 MCOLN3 229797_at 2.66 0.48
ectonucleotide pyrophosphatase/phosphodiesterase 5 ENPP5 227803_at 2.64 0.76
cathepsin K (pycnodysostosis) CTSK 202450_s_at 2.64 0.35
activating transcription factor 3 ATF3 202672_s_at 2.35 0.53
leucine-rich repeat-containing G protein-coupled receptor 7 LGR7 231804_at 2.28 0.10
disabled homolog 2, mitogen-responsive phosphoprotein DAB2 240873_x_at 2.27 0.31
solute carrier family 11, member 2 SLC11A2 203124_s_at 2.08 0.34
Homo sapiens transcribed sequences 229308_at 2.06 0.47
lymphocyte antigen 96 LY96 206584_at 2.04 0.43
DnaJ (Hsp40) homolog, subfamily B, member 4 DNAJB4 203811_s_at 2.00 0.30
solute carrier family 16, member 6 SLC16A6 230748_at 1.89 0.30
solute carrier family 11, member 2 SLC11A2 203123_s_at 1.88 0.06
signal transducer and activator of transcription 1 STAT1 209969_s_at 1.75 0.33
hypothetical protein dJ462O23.2 DJ462O23.2 214579_at 1.74 0.14
GM2 ganglioside activator protein GM2A 1559776_at 1.71 0.33
signal transducer and activator of transcription 1 STAT1 M97935_MA_at 1.71 0.26
interferon-induced protein with tetratricopeptide repeats 1 IFIT1 203153_at 1.68 0.13
hypothetical protein FLJ31715 FLJ31715 1553775_at 1.53 0.12
clone IMAGE:3632546 LOC643988 227185_at 1.50 0.10
carbonic anhydrase XI CA11 209726_at 1.48 0.18
prion protein (p27-30) PRNP 215707_s_at 1.37 0.15
SEC14-like 4 (S. cerevisiae) SEC14L4 239492_at 1.31 0.11
chromosome 20 open reading frame 22 C20orf22 228123_s_at 1.28 0.10
glutaredoxin (thioltransferase) GLRX 209276_s_at 1.23 0.09
Down-regulated in senescent passages
chemokine (C-X-C motif) ligand 6 CXCL6 206336_at −2.09 0.23
hyaluronan synthase 1 HAS1 207316_at −2.40 0.22
retinoic acid receptor responder (tazarotene induced) 1 RARRES1 221872_at −4.31 0.82
tumor necrosis factor (ligand) superfamily, member 11 TNFSF11 210643_at −6.10 1.46

36 Genes that were significantly differentially expressed between early and senescent passage of three independent donor samples (SAM, FDR = 3).