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. 2008 May 23;4(5):e1000072. doi: 10.1371/journal.ppat.1000072

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Symbols and virus nomenclature are as in Figure 1. The mouse infectious dose (MID₅₀) and lethal dose (LD₅₀) are expressed as the log₁₀ pfu required to give one MID₅₀ or one LD_50. Maximum mean weight loss was determined from five mice per group (percent weight loss relative to dpi 0) following intranasal infection with 10⁴ pfu. MST denotes the mean survival time in days following infection with 10⁴ pfu. Virus titer in lung, spleen, brain or nasal turbinate are geometric means of the log₁₀ pfu at 4 dpi of three mice infected with 10⁴ pfu. LD₅₀ values of rH5N1 in group A1 were significantly different from A2 and those from A1 and A2 were significantly different from TH04 WT (P<0.001) by analysis of variance. The — indicate that tissue titers were below limit of detection of the assay (0.7 log₁₀ pfu/ml). Viruses are listed in ascending LD₅₀ values. Viruses with identical LD₅₀ are listed by descending weight loss.