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. 2007 Aug;3(4):513–525.

Table 2.

Peptide deformylase inhibitors

A. Peptidic Inhibitors

  1. Thiol Class

  2. Pseudopeptidic Hydroxamic Acid or N-formyl-N-Hydroxyl-amine Class

    • Actinonin

    • BB-83698 (Vernalis, formerly British Biotech)

    • BB-3497 (Vernalis, formerly British Biotech)

    • VRC 3375

    • VRC 3324

    • VRC 4307

    • VRC 4887 (NVP PDF 386)

    • LBM-415 (NVP PDF 713) (VIC-104959) (Novartis, Vicuron)

    • LBK-611 (PDF-611) (Novartis)

  3. Metalloprotease Inhibitors

    • GMG001

    • TAP I-O

B. Non-Actinonin-Based, Non-Peptidic Inhibitors

  • β-sulfonylhydroxamic acid

  • β-sulfinylhydroxamic acid

  • 2 Bicyclic hydroxamic acids

  • Macrocyclic compound