Table 5.

Mean pharmacokinetic parameters for selected peptide deformylase inhibitors in mice and rats

Reference/species	Compound	Regimen	Cmax (mg/L)	Tmax (min.)	AUC (mg/L•h)	CL (mL/min/kg)	t 1/2 (h)	Vss(L/Kg)	F (%)
[Azoulay-Dupuiset al 2004]/mice	BB-83698	80 mg/kg SC × 1 dose	14.3a	60	57.4a,c	–	2.5a	–	–
			61.9b	60	229.4b,c	–	2.6b	–	–
[Ramanathan-Girish et al 2004]/ mice	BB-83698	10 mg/kg IV × 1 dose	6.3	–	3.8	44.4	1.0	2.0	–
		50 mg/kg IV × 1 dose	44.6	–	55.1	15.1	2.6	2.6	–
[Craig 2001]/ neutropenic mice	BB-83698	20 and 80 mg/kg SC and PO × 1 dose each	–	–	–	–	1.6–1.7	–	50
[Gross et al 2004]/ mice	BB-81384	10 mg/kg IV × 1 dose	15.1	–	6.5d	25	2.2	1.6	–
		10 mg/kg oral × 1 dose	1.6	–	3.6d	–	3.1	–	55
		50 mg/kg oral × 1 dose	21.3	–	28.6d	–	3.7	–	88
[Clements et al 2001]/rats	BB-3497	100 mg/kg oral × 1 dose	24.0	–	34e	–	–	–	–
[Chen et al 2004a]/ mice	VRC 3375	100 mg/kg IV × 1 dose	–	–	–	–	0.25	–	–
		100 mg/kg SC × 1 dose	66	20	–	–	0.25	–	–
		100 mg/kg PO × 1 dose	43	10	–	–	0.25	–	64
[Hackbarth et al 2002]/mice	VRC 4232	13 mg/kg IV × 1 dose	5580	–	–	–	1.1	–	–
		13 mg/kg oral × 1 dose	167	–	–	–	–	–	3.2
	VRC 4307	3.7 mg/kg IV × 1 dose	1720	–	–	–	0.1	–	–
		3.7 mg/kg oral × 1 dose	1.5	15	–	–	–	–	0.1
[Teo et al 2006]/ mice	PDF-611	1 mg/kg IV × 1 dose	604f	–	254g	65.8	0.5	3.0	–
		5 mg/kg oral × 1 dose	194f	15	566g	–	3.7	–	45

Abbreviations:C_max = peak plasma concentration, T_max = time to C_max, AUC = area under the plasma concentration-versus-time curve, CL = total body clearance, t 1/2 = terminal disposition half-life, V_ss = volume of distribution at steady-state, F = oral bioavailability.

^aserum.

^blung.

^cOver 10 hrs. post-dose.

^dOver 5 hrs. post-dose.

^eOver 24 hrs. post-dose.

^fng/mL.

^gng/mL•h.