Table 1.

Gastric acidity, expressed as the percentage of time with intragastric pH >4.0 on day 5 in individuals treated with esomeprazole, omeprazole, pantoprazole, and rabeprazole in cross-over randomized pharmacodynamic studies

Reference	Study design	Patient/individual selection	PPIs compared	Number of individuals	Percentage of time with intragastric pH >4.0
Lind et al 2000	Double-blind, randomized, cross-over	GERD symptoms	Eso40 vs eso20 vs ome 20 od	38	69.8% vs 53.0 vs 43.7% p < 0.01
Rohss et al 2002	Open-label, randomized, cross-ove	GERD symptoms	Eso40 vs ome 40 od	130	68.4% vs 62.0%, p < 0.001
Wilder-Smith et al 2003	Open-label, randomized, cross-over	Healthy volunteers	Eso40 vs lan30 od	24	65% vs 53%, p < 0.001
Wilder-Smith et al 2003	Open-label, randomized, cross-over	Healthy volunteers	Eso40 vs rabe20 od	23	61% vs 45.1%, p = 0.005
Miner et al 2003	Open-label, randomized, cross-over	GERD symptoms	Eso40 vs lan30 vs ome20 vs panto40 vs rabe20 od	34	58.4% vs 47% vs 49.1 vs 50.5%, p < 0.001
Rohss et al 2004	Open-label, randomized cross-over	GERD symptoms	Eso40 vs lan30 od	36	57.5% vs 44.6%, p < 0.0001
Rohss et al 2004	Open-label, randomized, cross-over	GERD symptoms	Eso40 vs ome20 od	38	70% vs 43.8%, p < 0.0001
Rohss et al 2004	Open-label, randomized, cross-over	GERD symptoms	Eso40 vs panto40 od	32	67.1% vs 45%, p < 0.001
Rohss et al 2004	Open-label, randomized, cross-over	GERD symptoms	Eso40 vs rabe20 od	35	59.6% vs 44.6%, p < 0.0001
Miehlke et al 2005	Single-blind, randomized, cross-over	Healthy volunteers	Eso40 vs panto bd	30	85.4% vs 63.6%, p = 0.0001
Johnson et al 2005	Open-label, randomized, cross-over	GERD symptoms 2005	Eso40 bd vs lan30 bd vs eso40 od vs lan30 od	45	81.3% vs 65.4% vs 60.1% vs 51.3% p < 0.05

Abbreviations: Eso, esomeprazole; GERD, gastroesophageal reflux disease; lan, lansoprazole; ome, omeprazole; PPI, proton-pump inhibitor; panto, pantoprazole; rabe, rabeprazole.