Table 2.

Randomized trials evaluating the efficacy of esomeprazole vs other proton-pump inhibitors in healing erosive GERD

Reference	Study design	Number of patients	PPIs compared	Healing rates intention-to-treat analysis
				4 weeks	8 weeks
Kahrilas et al 2000	Double-blind, randomized	1960	Eso40 vs eso20 vs ome20 od	75.9% vs 70.5% vs 64.7%, p < 0.05 for eso40 vs p = 0.09 for eso20 vs ome20	94.1% vs 89.9% vs 86.9%, p < 0.05 for all comparisons
Richter et al 2001	Double-blind, randomized	2425	Eso40 vs ome20 od	81.7% vs 68.7%, p < 0.001	93.7% vs 84.2%, p < 0.001
Schmitt et al 2006	Double-blind, randomized	1148	Eso40 vs ome20 od	68.2% vs 66.3%, p = 0.385	87% vs 85.8, p = 0.552
Castell et al 2002	Double-blind, randomized	5241	Eso40 vs lan30 od	79.4% vs 75.1%, p < 0.05	92.6% vs 88.8%, p < 0.0001
Howden et al 2002	Double-blind, randomized	284	Eso40 vs lan30 od	78.3% vs 77%, p > 0.05	91.4% vs 89.1, p > 0.05
Fennerty et al 2005	Double-blind, randomized	1001	Eso40 vs lan30 od	55.8% vs 47.5%, p = 0.005	82.4% vs 77.5%, p = 0.005
Gillessen et al 2004	Double-blind, randomized	227	Eso40 vs panto40 od	72% vs 74%, p > 0.05a	92% vs 90%, p > 0.05b
Labenz et al 2005b	Double-blind, randomized	3170	Eso40 vs panto40 od	81% vs 74.5%, p < 0.001	92% vs 95.5%, p < 0.001

^aHealing rates regarding the first follow-up visit at 4 or 6 weeks in this study

^bHealing rates at the second follow-up visit at 8 or 10 weeks in this study

Notes: No randomized studies comparing esomeprazole with rabeprazole for healing erosive GERD were found.

Abbreviations: Eso, esomeprazole; ome, omeprazole; lan, lansoprazole; panto, pantoprazole; PPI, proton-pump inhibitor.