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NHERF1 increases caspase-3 cleavage in response to STI-571. Cultured (a) MCF10A and (b) Zr75.1 cells of varying Na+/H+ exchanger regulatory factor 1 (NHERF1) expression level were treated with STI-571 for 1 day. Cells were then lysed and separated by SDS-PAGE. Immunoblotting was used to detect caspase-3 (8G10). The caspase-3 antibody recognized both the full-length (35 kDa [arrow]) and the large fragment (17/19 kDa [arrowhead]) of caspase-3 resulting from cleavage.
