Table 4.
Univariate and Multivariate Cox-regression model
| ER- (n = 186) | ER+ (n = 527) | |||
| HR (95% CI) | P | HR (95% CI) | P | |
| LN | 2.28 (1.36-3.85) | 0.002 | 2.07 (1.47-2.90) | <10-4 |
| LI | 1.06 (0.66-1.70) | 0.9 | 1.50 (0.72-3.14) | 0.58 |
| IRM | 2.02 (1.19-3.41) | 0.009 | 1.25 (0.91-1.71) | 0.19 |
| LNa + IRM | 2.16 (1.28-3.64) | 0.004 | 2.10 (1.49-2.96) | <10-4 |
| LN + IRMa | 1.93 (1.14-3.26) | 0.015 | 1.29 (0.94-1.76) | 0.11 |
| LIa + IRM | 0.86 (0.32-2.28) | 0.76 | 1.75 (0.41-7.47) | 0.45 |
| LI + IRMa | 2.05 (0.71-5.97) | 0.19 | 0.57 (0.27-1.19) | 0.13 |
| LNa + LI + IRM | 1.79 (0.70-4.62) | 0.22 | 1.48 (0.68-3.19) | 0.32 |
| LN + LIa + IRM | 0.84 (0.51-1.38) | 0.72 | 1.65 (0.38-7.07) | 0.5 |
| LN + LI + IRMa | 2.22 (0.76-6.50) | 0.15 | 0.57 (0.27-1.20) | 0.14 |
The table summarizes the hazard ratio (HR), 95% confidence interval (CI), and log-rank test P values of univariate Cox proportional hazards regression models, with lymph node status (LN = 1/0 for LN +/-), level of lymphocytic infiltration (LI = 1 for low infiltration score, and LI = 0 for high infiltration score) and the classification based on the seven-gene immune response related module (IRM; 2 = down-regulation of module, 1 = upregulation of module) as predictors. aCorresponding values in the multivariate Cox models including LN, LI, and IR module as predictors. The table compares the values for estrogen receptor (ER)- and ER+ breast cancer.