Table 1.
Differentially represented Gene Ontology categories
| Category | Term | Count* | Percent† | P value‡ |
| Biological process | Lipid metabolism | 110 | 6.10 | 3.10E-09 |
| Steroid metabolism | 41 | 2.30 | 9.90E-09 | |
| Cellular lipid metabolism | 78 | 4.30 | 9.30E-08 | |
| Response to toxin | 34 | 1.90 | 4.20E-06 | |
| Response to biotic stimulus | 94 | 5.20 | 7.90E-06 | |
| Transport | 309 | 17.10 | 9.20E-06 | |
| Defense response | 92 | 5.10 | 9.60E-06 | |
| Response to chemical stimulus | 66 | 3.60 | 9.80E-06 | |
| Response to abiotic stimulus | 84 | 4.60 | 1.20E-05 | |
| Localization | 352 | 19.40 | 1.40E-05 | |
| Metabolism | 799 | 44.10 | 1.70E-05 | |
| DNA-dependent DNA replication | 22 | 1.20 | 3.60E-05 | |
| Establishment of localization | 340 | 18.80 | 3.70E-05 | |
| Physiological process | 1,041 | 57.50 | 4.30E-05 | |
| DNA replication | 36 | 2.00 | 1.60E-04 | |
| Cellular physiological process | 958 | 52.90 | 2.50E-04 | |
| Secretion | 48 | 2.70 | 2.80E-04 | |
| Electron transport | 74 | 4.10 | 3.00E-04 | |
| Response to stress | 66 | 3.60 | 3.20E-04 | |
| Response to stimulus | 191 | 10.50 | 3.50E-04 | |
| Secretory pathway | 45 | 2.50 | 4.30E-04 | |
| Response to endogenous stimulus | 31 | 1.70 | 7.80E-04 | |
| Response to DNA damage stimulus | 28 | 1.50 | 8.10E-04 | |
| Sleep | 7 | 0.40 | 1.00E-03 | |
| Primary metabolism | 705 | 38.90 | 1.50E-03 | |
| Protein complex assembly | 28 | 1.50 | 2.60E-03 | |
| Intracellular transport | 99 | 5.50 | 2.90E-03 | |
| DNA repair | 25 | 1.40 | 2.90E-03 | |
| Intracellular protein transport | 80 | 4.40 | 3.90E-03 | |
| Regulation of neurotransmitter levels | 26 | 1.40 | 4.20E-03 | |
| Cell organization and biogenesis | 221 | 12.20 | 4.40E-03 | |
| Cellular localization | 101 | 5.60 | 4.50E-03 | |
| Protein localization | 91 | 5.00 | 4.60E-03 | |
| Heterophilic cell adhesion | 6 | 0.30 | 4.70E-03 | |
| Proteolysis | 129 | 7.10 | 5.20E-03 | |
| Establishment of cellular localization | 100 | 5.50 | 5.70E-03 | |
| Oxygen and reactive oxygen species metabolism | 18 | 1.00 | 6.20E-03 | |
| Sulfur metabolism | 15 | 0.80 | 7.00E-03 | |
| Generation of precursor metabolites and energy | 92 | 5.10 | 7.50E-03 | |
| Cellular metabolism | 711 | 39.30 | 7.70E-03 | |
| Neurotransmitter secretion | 23 | 1.30 | 8.00E-03 | |
| Regulated secretory pathway | 23 | 1.30 | 8.00E-03 | |
| mRNA export from nucleus | 7 | 0.40 | 8.40E-03 | |
| Establishment of protein localization | 82 | 4.50 | 8.90E-03 | |
| Sterol metabolism | 10 | 0.60 | 9.00E-03 | |
| Macromolecule metabolism | 498 | 27.50 | 9.70E-03 | |
| Chromosome condensation | 9 | 0.50 | 1.00E-02 | |
| Nuclear transport | 16 | 0.90 | 1.00E-02 | |
| Molecular function | Catalytic activity | 639 | 35.30 | 3.60E-10 |
| Monooxygenase activity | 38 | 2.10 | 1.50E-07 | |
| Oxidoreductase activity | 131 | 7.20 | 1.40E-06 | |
| Protein binding | 693 | 38.30 | 2.60E-06 | |
| Transporter activity | 208 | 11.50 | 1.40E-05 | |
| Electron transporter activity | 49 | 2.70 | 9.40E-05 | |
| Hydrolase activity | 294 | 16.20 | 2.70E-04 | |
| Sequence-specific DNA binding | 12 | 0.70 | 4.40E-04 | |
| Tetrapyrrole binding | 16 | 0.90 | 1.30E-03 | |
| Heme binding | 16 | 0.90 | 1.30E-03 | |
| Binding | 990 | 54.70 | 1.80E-03 | |
| Carbon-carbon lyase activity | 14 | 0.80 | 2.60E-03 | |
| Electrochemical potential-driven transporter activity | 43 | 2.40 | 2.80E-03 | |
| Porter activity | 43 | 2.40 | 2.80E-03 | |
| Calmodulin binding | 18 | 1.00 | 3.60E-03 | |
| Carbohydrate transporter activity | 19 | 1.00 | 5.10E-03 | |
| Phosphoric monoester hydrolase activity | 36 | 2.00 | 6.50E-03 | |
| DNA-directed DNA polymerase activity | 10 | 0.60 | 6.60E-03 | |
| Sugar porter activity | 12 | 0.70 | 7.40E-03 | |
| Glutathione transferase activity | 11 | 0.60 | 8.70E-03 | |
| Sugar transporter activity | 13 | 0.70 | 1.00E-02 | |
| Cellular component | Microsome | 31 | 1.70 | 5.80E-10 |
| Vesicular fraction | 31 | 1.70 | 5.80E-10 | |
| Cell fraction | 34 | 1.90 | 1.20E-09 | |
| Membrane fraction | 33 | 1.80 | 2.10E-09 | |
| Clathrin coat | 9 | 0.50 | 3.80E-04 | |
| Replication fork | 9 | 0.50 | 3.80E-04 | |
| Coated membrane | 11 | 0.60 | 6.70E-04 | |
| Membrane coat | 11 | 0.60 | 6.70E-04 | |
| Clathrin vesicle coat | 8 | 0.40 | 1.10E-03 | |
| Clathrin coated vesicle membrane | 8 | 0.40 | 1.10E-03 | |
| Golgi apparatus | 24 | 1.30 | 1.40E-03 | |
| Coated pit | 5 | 0.30 | 1.50E-03 | |
| Cell | 673 | 37.20 | 1.60E-03 | |
| Cytoplasmic vesicle membrane | 10 | 0.60 | 1.70E-03 | |
| Vesicle coat | 10 | 0.60 | 1.70E-03 | |
| Coated vesicle membrane | 10 | 0.60 | 1.70E-03 | |
| Cytoplasm | 239 | 13.20 | 2.90E-03 | |
| Membrane | 295 | 16.30 | 3.00E-03 | |
| Plasma membrane | 83 | 4.60 | 3.80E-03 | |
| Alpha DNA polymerase | 4 | 0.20 | 4.30E-03 | |
| Chromosome | 40 | 2.20 | 5.00E-03 |
*Number of genes in the annotation category. †Number of genes in the annotation category/total number of significant genes. ‡P value from a modified Fisher exact test for enrichment of genes in an annotation category. The cross-classified factors in the 2 × 2 contingency tables are genes in the annotation category versus not in the annotation category, and significant genes versus all genes on the array.