Table 3.

The most prevalent bio-ligands in the fold universe (shared by 15+ folds) and the most common folds used by host proteins of each ligand

Ligands	Number of folds	Most common folds
Adenosine-5'-triphosphate (ATP)	35	P-loop containing nucleoside triphosphate hydrolases (c.37)
Adenosine-5'-diphosphate (ADP)	31	P-loop containing nucleoside triphosphate hydrolases (c.37)
Guanosine-5'-diphosphate (GDP)	29	P-loop containing nucleoside triphosphate hydrolases (c.37)
Nicotinamide-adenine-dinucleotide (NAD)	27	NAD(P)-binding Rossmann-fold domains (c.2)
Flavin-adenine dinucleotide (FAD)	21	FAD/NAD(P)-binding domain (c.3)
Dihydro-nicotinamide-adenine-dinucleotide phosphate (NDP)	18	NAD(P)-binding Rossmann-fold domains (c.2)
Nicotinamide-adenine-dinucleotide phosphate (NAP)	16	NAD(P)-binding Rossmann-fold domains (c.2)
Flavin mononucleotide (FMN)	16	Flavodoxin-like (c.23)
Adenosine monophosphate (AMP)	15	Adenine nucleotide alpha hydrolase-like (c.26)