Figure 3.

Two-sided binomial test on the data from Krogan and coworkers [11]. The scatter-plot shows (o_p,i_p) for each p ∈ VBP from the report by Krogan and coworkers [11] (axes are scaled by the square root). The proteins that fall outside of the diagonal band exhibit high asymmetry in unreciprocated degree. This figure shows a graphical representation of a two-sided binomial test. The points above and below the diagonal band are proteins for which we reject the null hypothesis that the distribution of unreciprocated edges is governed by B(n_p,$\frac{1}{2}$). For the purpose of visualization, small random offsets were added to the discrete coordinates of the data points by the R function jitter. VBP, viable bait/prey.