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. 2008 May 21;3(5):e2236. doi: 10.1371/journal.pone.0002236

Figure 6. miR-17-5p expression is correlated to MYCN and p21 levels in human primary neuroblastomas.

Figure 6

(A) Expression of MYCN, miR-17-5p and p21 was analyzed in primary tumors by qRT-PCR. Depending on the expression levels of MYCN and miR-17-5p, primary tumors were divided into three groups. Group 1 (left upper panel) includes MYCN-amplified tumors displaying high levels of miR-17-5p and very low levels of p21. Group 2 (right upper panel) includes MYCN-not-amplified tumors expressing low levels of miR-17-5p and high levels of p21. Group 3 (lower panel) includes MYCN-not-amplified tumors expressing high levels of miR-17-5p and moderately low levels of p21 (a 40% decrease baseline is shown). The coloured boxes indicate the tumor stage (from I to IV) and the therapy resistant tumors (TR). (B) Expression of MYCN, miR-17-5p and p21 in the three groups of primary tumors. Mean±s.d.. ** P<0.01, *** P<0.001 when compared to second group; °°° P<0.001 when compared to the other groups.