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. 2002 Feb 12;86(4):636–644. doi: 10.1038/sj.bjc.6600100

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Copyright © 2002 Cancer Research UK

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Antiproliferative and cell cycle effects of nucleotides. (A) Extracellular ATP (⋄) and ATPγS (□) significantly decreased the cell number of Kyse-140 cells after 3 days of incubation in a dose-dependent manner (P<0.05 for 100–500 μM). In contrast, 2MeSATP (○) or adenosine (Δ) showed no or minor effects. The respective antiproliferative effects are given as the percentage of cells of the untreated controls (=100%). Means±s.e.m. of four independent experiments are shown. (B) After 24 h of incubation both ATP and ATPγS altered the proportion of cells in the G1/G0-phase (white columns), S-phase (hatched columns), and G2/M-phase (black columns) of the cell cycle. Means±s.e.m. of six independent experiments are shown.