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. 2002 Feb 12;86(4):564–567. doi: 10.1038/sj.bjc.6600076

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Copyright © 2002 Cancer Research UK

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Immunohistochemical staining for hMLH1 protein expression in gastric cancers with unmethylated (A) or hypermethylated (B) gene promoters. (A) Nuclear staining of hMLH1 in a MSS tumour without promoter hypermethylation (intramucosal well differentiated tubular adenocarcinoma). (B) Loss of hMLH1 expression in a MSI-H tumour with promoter hypermethylation (left, intramucosal well differentiated tubular adenocarcinoma; right, intestinal metaplastic mucosa exhibiting hMLH1 expression).