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. 2002 Feb 12;86(4):645–651. doi: 10.1038/sj.bjc.6600082

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Copyright © 2002 Cancer Research UK

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Ang1-overexpression coincides with a decrease of cancer cell proliferation and apoptosis. Tumour sections were immunostained for PCNA with DAB-Ni substrate (black), counter stained with Gill's haematoxylin (blue). Original magnification ×400. (a) Microscopic image of a section of MCF-7 tumours. (b) Microscopic image of a section of Ang1-overexpressing tumours. Apoptotic cells are identified by in-situ TUNEL labelling visualized with TMR-Red (red). Original magnification ×200. (c) Confocal microscopic image of a typical apoptotic cell population in the control parental MCF-7 tumours. (d) Confocal microscopic image of the Ang1-overexpressing tumours.