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. 2002 Mar 4;86(5):819–827. doi: 10.1038/sj.bjc.6600103

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Copyright © 2002 Cancer Research UK

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Typical dose-effect curves comparing sequences I and III for (A, B) Hep-2 and (C, D) CAL33. Sequence I consisted of ZD1839, followed by cisplatin/5-FU for 48 h; sequence III was ZD1839 applied first and also during the cisplatin/5-FU exposure, followed by medium for 48 h.