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. 2002 Jun 5;86(11):1831–1836. doi: 10.1038/sj.bjc.6600343

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Copyright © 2002 Cancer Research UK

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Effect of necrosis on median EF5/Cy3 intensities as a function of distance from nearest total blood vessel (CD31 staining). Each curve is based on the combination of four image montages from a single untreated tumour, and percentages of gross necrosis and tumour volumes are as follows: filled circles=4%, 520 mm³; open circles=18%, 900 mm³; filled triangles=28%, 1150 mm³; open triangles=67%, 1770 mm³. Intensities are presented as the median intensity within each 20 μm wide zone.