Figure 4. Reduction in cutaneous vascular conductance (CVC) during cold stress before drug infusion (upper panel) and after CVC was increased via adenosine with or without NG-nitro-l-arginine methyl ester (l-NAME; lower panel).
The reduction in CVC during the first cold stress was similar between sites. Adenosine with or without l-NAME increased CVC ∼3-fold from the level before drug infusion. Prior to the second cold stress, although baseline CVC was not different between sites, the reduction in CVC to this cold stress was significantly greater at the adenosine + l-NAME site compared to the adenosine alone site. *P < 0.05.