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. 2007 May 3;585(Pt 3):693–698. doi: 10.1113/jphysiol.2007.134346

Figure 1. Structure and localization of SNAREs involved in exocytosis.

Figure 1

SNAP-25 and SNAP-23 possess two SNARE motifs connected by a linker region which is attached to the membrane via 4 (SNAP-25) or 5 (SNAP-23) palmitoyl anchors. All other exocytotic SNAREs are associated with the membrane via a TMR that is C-terminally attached to their SNARE motif, and only syntaxins have in addition an independently folded N-terminal domain connected to the SNARE motif via a linker region. According to the SNARE hypothesis, membrane fusion is mediated by complex formation between the SNARE motifs of the SNAREs localized on the opposed membranes destined to fuse.