Figure 1. Baseline short-circuit current (I_SC) is increased in late distal colon tissue of mice with Liddle's syndrome mutation and is sensitive to amiloride.

Representative short-circuit current (I_SC) traces are shown (left panels) which were recorded using colon tissue preparations from wild-type animals (WT) or from animals that were heterozygous (+/L) or homozygous (L/L) for Liddle's syndrome mutation. Animals used for these experiments were maintained on a standard salt diet. Amiloride (Ami) in a concentration of 10⁻⁴m was present in the apical (ap) bath solution during the period indicated by the black bar. The columns (right panels) summarize data from similar experiments, as shown in the corresponding traces. Average I_SC values before (base line) and after the application of amiloride (Ami) are shown. The baseline I_SC in L/L animals compared with that in wild-type animals was significantly increased (P < 0.05).