Figure 4. Even at a concentration of 0.3 nmin vitro application of aldosterone has a significant stimulatory effect on colonic I_SC in animals of all three genotypes (WT, +/L and L/L).

Animals were exposed to high salt diet for 2 weeks prior to the experiment in order to suppress endogenous aldosterone levels. Experiments were performed as in Fig. 3. Average I_SC values are shown in A, while ΔI_SC-Ami values are summarized in B.